Helicobacter Pylori Genome Project (HpGP)

Objective: to study the genetic variations of H. pylori strains based on samples from chronically infected people to determine the characteristics of strains that can lead to serious stomach problems or stomach cancer.

Dates: 2016-2021

Funding: initiative

Consortium members: Greece, Honduras, Latvia, Lithuania, Mexico, Peru, Taiwan, Brazil, Canada, Chile, Egypt, Guatemala, Bulgaria, Romania, India, Iran, Italy, Japan, Kazakhstan, Kyrgyzstan, Korea, Kuwait, Spain, Sudan, Sweden, Turkey and the United States.

Participants from Kyrgyzstan: Marina Moldobaeva-MD, Professor, Head of the Department of Propaedeutics of Internal Diseases with the course of Endocrinology; Rakhat Attokurova-Assistant of the Department.

Participation in the Research: biomaterial was collected from 40 patients with chronic gastritis, which was sent to the United States for further study. The collection, storage and transport of biomaterials was carried out in accordance with the Sydney Protocol. The degree of atrophy was determined by the OLGA system. Currently, the genome is being sequenced in the United States, and the results are being processed until May-the month of 2021. In September 2021, it is planned to publish an article on the results of the research of this project.

Nr	Patient nr	Origin	Culture	Hp status	Diagnosis
1	ChMA	Bishkek		positive	Hypertrophic gastritis OLGA II
2	DKI	Bishkek		positive	Hypertrophic gastritis. Duodenitis OLGA II
3	AAS	Bishkek		positive	Superficial gastroduodenitis OLGA II
4	KKA	Bishkek		positive	Hypertrophic gastritis OLGA 0
5	SAS	Bishkek		positive	Erosive gastritis OLGA II
6	KSM	Bishkek		positive	Erosive gastritis OLGA II
7	SJZ	Bishkek		positive	Superficial gastritis OLGA III
8	DKA	Bishkek		positive	Superficial gastritis OLGA IV
9	MAK	Bishkek		positive	Superficial gastritis OLGA II
10	ABN	Bishkek		positive	Superficial gastritis OLGA IV
11	OAM	Bishkek		positive	Superficial gastritis OLGA II
12	MTSh	Bishkek		positive	Superficial gastritis OLGA IV
13	BSS	Bishkek		positive	Superficial gastritis OLGA IV
14	KRA	Bishkek		positive	Antrum erosion OLGA III
15	MB	Bishkek		positive	Superficial gastritis OLGA IV
16	BMK	Bishkek		positive	Superficial gastritis OLGA III
17	MUM	Bishkek		positive	Hypertrophic gastritis OLGA II
18	NES	Bishkek		positive	Hypertrophic gastritis OLGA I
19	BMB	Bishkek		positive	Superficial gastritis OLGA IV
20	KKA	Bishkek		positive	Superficial gastritis OLGA IV
21	UII	Bishkek		positive	Hypertrophic gastritis OLGA IV
22	BUJ	Bishkek		positive	Hypertrophic gastritis OLGA II
23	ShSK	Bishkek		positive	Hypertrophic gastritis OLGA III
24	SDM	Bishkek		positive	Superficial gastritis OLGA III
25	PUS	Bishkek		positive	Superficial gastritis OLGA III
26	PB	Bishkek		positive	Superficial gastritis OLGA II
27	AJM	Bishkek		positive	Superficial gastritis OLGA IV
28	NMS	Bishkek		positive	Superficial gastritis OLGA III
29	JBA	Bishkek		positive	Superficial gastritis, DGR OLGA IV
30	KDT	Bishkek		positive	Superficial gastritis OLGA IV
31	MNK	Bishkek		positive	Hypertrophic gastritis OLGA III
32	MAS	Bishkek		positive	Superficial gastritis OLGA IV
33	NMM	Bishkek		positive	Hypertrophic gastritis OLGA III
34	JM	Bishkek		positive	Hypertrophic gastritis OLGA III
35	ShUM	Bishkek		positive	Superficial gastritis OLGA IV
36	II	Bishkek		positive	Hypertrophic gastritis OLGA IV
37	TDT	Bishkek		positive	Hypertrophic gastritis OLGA IV
38	BAA	Bishkek		positive	Superficial gastritis OLGA II
39	KND	Bishkek		positive	Superficial gastritis OLGA IV
40	SKhS	Bishkek		positive	Superficial gastritis. DGR OLGA IV

Ссылка на сайт: https://clinicaltrials.gov/ct2/show/study/NCT02788214?term=HpGP&draw=2&rank=1